How to Start Tretinoin: Tips to Avoid Dryness, Redness, and Peeling

Tips for Starting Tretinoin Without the “Retinoid Uglies”
Tretinoin is one of the most effective prescription treatments for acne and anti-aging. But if you’ve just started using it, you may experience irritation — dryness, redness, or peeling. This adjustment period is often called the “retinoid uglies.” The good news? It doesn’t last forever, and there are ways to minimize it.
1. Start Slowly
Don’t rush into daily use. Begin with 2–3 nights per week, then increase as your skin adjusts.
2. Moisturize Generously
Apply a gentle, hydrating moisturizer after tretinoin. Some people even use the “sandwich method” — moisturizer → tretinoin → moisturizer — for extra protection.
3. Use a Mild Cleanser
Avoid harsh scrubs or foaming washes. Stick to a gentle, fragrance-free cleanser that won’t strip your skin.
4. Always Wear Sunscreen
Tretinoin makes skin more sensitive to sunlight. Apply broad-spectrum SPF 30+ daily to prevent irritation and sun damage.
5. Be Patient
The adjustment phase usually lasts a few weeks. With consistent use, most people notice clearer, smoother skin within 8–12 weeks.
✅ Takeaway: The “retinoid uglies” are temporary. By starting slow, moisturizing, and protecting your skin, you can successfully transition into tretinoin and enjoy its long-term benefits.